Dr. Axia Marlin
Post-Doc
Chimie ParisTech
PSL University
CNRS
Institute of Chemistry for Life and Health Sciences
Laboratory for Inorganic Chemical Biology
+33 1 44 27 56 04
axia.marlin@chimieparistech.psl.eu
Axia is native of La Reunion (974), overseas department of France. After obtaining her master’s degree in chemistry at Université de Paul Sabatier in Toulouse (France), she moved to Brest for her PhD, working under the supervision of Pr. Raphaël Tripier and Dr. Véronique Patinec where she investigated triazamacrocyclic-based chelators for transition metals complexation for cancer imaging and therapy. In 2022 she then moved to the US to work as postdoc in the Pr. Eszter Boros’s group where she led a chemical biology project studying the mechanism of action of natural product-based metal complexes conjugated to antibiotic active against Gram positive bacteria. She also became proficient in in vitro and in vivo radiochemical experiments as well as PET/CT imaging. Axia joined the Gasser Group in 2025 as a postdoc to work on Ru-complex polymers for ovarian cancer treatment and prepare for the CNRS as Chargé de Recherche.
Axia is mixed introvert/extrovert. She enjoys her time alone traveling, exploring, hiking, eating good food. She also likes going outside for apéro with friends to fulfill her social energy. She also likes climbing, going to the gym for boxing and Zumba. Axia also enjoys going back to her island (for short period of time) to visit family and her cat Maloune!
Award
- Prix de la meilleure communication aux Journées Scientifiques SCF BPL, Rennes (France),
Publications
[1] Axia Marlin, Fiona Le Pape, Thibault Troadec, Jocelyn Le Goff, Raphael Tripier, Christian Berthou, Veronique Patinec, Zn2+ triazamacrocyclic chelators with methylpyridine pendant arms for B-cells apoptosis: a structure-activity study, Dalton Trans. 2024, 54, 3939-3951, doi.org/10.1039/D4DT02962C
[2] Jennifer N Whetter, Dariusz Śmiłowicz, Kaelyn V Becker, Eduardo Aluicio-Sarduy, Cormac AA Kelderman, Angus J Koller, Owen M Glaser, Axia Marlin, Shin Hye Ahn, Margarita N Kretowicz, Jonathan W Engle, Eszter Boros, Phosphonate-Based Aza-Macrocycle Ligands for Low-Temperature, Stable Chelation of Medicinally Relevant Rare Earth Radiometals and Radiofluorination, J. Am. Chem. Soc. 2024, 146, 48, 33121–33129, doi.org/10.1021/jacs.4c11254
[3] Daniel Torralba-Maldonado, Axia Marlin, Fátima Lucio-Martínez, Antía Freire-García, Jennifer Whetter, Isabel Brandariz, Emilia Iglesias, Paulo Pérez-Lourido, Rosa M Ortuño, Eszter Boros, Ona Illa, David Esteban-Gómez, Carlos Platas-Iglesias, Tuning the Properties of Rigidified Acyclic DEDPA2– Derivatives for Application in PET Using Copper-64, Inorg. Chem. 2024, 63, 46, 22297–22307, doi.org/10.1021/acs.inorgchem.4c04050
[4] Axia Marlin, Angus Koller, Enikö Madarasi, Marie Cordier, David Esteban-Gómez, Carlos Platas-Iglesias, Gyula Tircsó, Eszter Boros, Véronique Patinec, Raphaël Tripier, H3nota Derivatives Possessing Picolyl and Picolinate Pendants for Ga3+ Coordination and 67Ga3+ Radiolabeling, Inorg. Chem. 2023, 62, 50, 20634–20645, doi.org/10.1021/acs.inorgchem.3c01417
[5] Raphael Lengacher, Axia Marlin, Dariusz Śmiłowicz, Eszter Boros, Medicinal inorganic chemistry–challenges, opportunities and guidelines to develop the next generation of radioactive, photoactivated and active site inhibiting metal-based medicines, Chem. Soc. Rev., 2022,51, 7715-7731, doi.org/10.1039/D2CS00407K
[6] Axia Marlin, Ina Hierlmeier, Amaury Guillou, Mark Bartholomä, Raphaël Tripier, Véronique Patinec, Bioconjugated chelates based on (methylpyridinyl)tacn: synthesis, 64Cu labeling and in vitro evaluation for prostate cancer targeting, Metallomics 2022, 14, mfac036, doi.org/10.1093/mtomcs/mfac036.
[7] Axia Marlin, Fiona Le Pape, Jocelyn Le Goff, Nadège Hamon, Thibault Troadec, Raphaël Tripier, Christian Berthou, Véronique Patinec, New triazacycloalkane derivatives as cytotoxic agents for CLL treatment: From proof of concept to the targeting biomolecule, Bioconjugate Chem. 2022, 33, 7, 1377–1392, doi.org/10.1021/acs.bioconjchem.2c00227