Dr. Malay Patra
Senior Scientist
Room 34-H-40
+41 44 635 46 86
malay.patra@gassergroup.com
Malay was born in a small and beautiful village near Kolkata, India in 1984. After finishing his high school and bachelor study in chemistry, he decided to move to Mumbai (in the west part of India) in 2005. In the year 2007, he graduated from Indian Institute of Technology Bombay (IIT-Bombay) with a M. Sc. in chemistry. During his master study, he was working on the project ‘Synthetic, Redox and Reactivity Aspects of [Ru(trpy)(pip)(NO)]3+ Involving Electrophilic Nitrosyl Function (trpy = 2,2/:6/,2//-Terpyridine, pip = 2-phenylimidazo[4,5-f][1,10] phenanthroline)’ under the supervision of Prof. G. K. Lahiri, department of chemistry, IIT-Bombay.
In September, 2007, Malay flew to Germany to join the group of Prof. Nils Metzler-Nolte, Ruhr University Bochum as a Ph.D. student. There, he was working on his Ph. D. thesis entitled ‘Design, Synthesis and Biological evaluation of Organometallic Antibacterial Agents’. In July, 2011, Malay finished his doctoral study with distinction.
Soon after that Malay moved to Zurich in August, 2011, to start his Postdoctoral study in the Gasser group at University of Zurich where he was involved in several projects. One of his key findings in area of radiopharmaceuticals is the development of the first octadentate bifunctional octadentate chelator for PET emitter 89Zr. He was also actively involved in designing novel metal-based antiparasitic and anticancer agents.
In September 2013, Malay started working as a postdoctoral associate at the group of Prof. Stephen J. Lippard, MIT, Cambridge, USA. His main research at MIT focused on designing next generation of platinum anticancer drug candidates with cancer targeting properties. For targeting the overexpressed glucose-transporters and enhanced metabolite flux in cancer cells, he developed glucose-conjugated platinum compounds that internalize through the membrane bound glucose-transporters and selectively accumulate in and annihilate cancers while being non-toxic or less toxic to healthy cells.
In December 2015, he started as a senior scientist in the group of Prof. Gilles Gasser at University of Zurich, Switzerland. He is currently working on the preparation of prodrug candidates.
Apart from Chemistry, Malay is very much interested in doing sports, listening songs, travelling and watching movies.
Awards
2010 Rubitec Award from the Ruhr-University Bochum for the patent application “Metal-Containing Platensimycin Analogues”, which was selected as one of the best patent application submitted in 2009 within the Ruhr-University Bochum..
2007 Max Planck Research Fellowship from the Internation Max Planck Research School in Chemical Biology (IMPRS-CB), Dortmund, Germany.
2006 Merit-Cum-Means Scholarship from the Indian Institute of Technology, Bomby, India.
Patents and Patents Applications
[8] N. Metzler-Nolte, G. Gasser, M. Patra. Metal-containing platensimycin analogues; EP2226329 A1 (2010).
[7] T. L. Mindt, A. Baumann, M. Patra, G. Gasser. Octacoordinating zirconium ligands and their use in diagnostic imaging and therapy; Eur. Pat. Appl. (2014), EP14160792.9.
[6] G. Gasser, A. Leonidova, T. Joshi, D. Nipkow, A. Frei, J.-E. Penner, S. Konatschnig and M. Patra. Synthesis of amino-substituted metallocene compounds; Eur. Pat. Appl. (2013), EP13157319.8.
[5] G. Gasser, R. B. Gasser, J. Hess, M. Patra, A. Jabbar. Organometallic 2-cyano-2- aminobenzoate-propyl derivatives and their use as anthelmintic; PCT/EP2014/064005.
[4] G. Gasser, R. B. Gasser, J. Hess, M. Patra, A. Jabbar, B. R. Ansell. N-(1-cyano-2-hydroxy-1-methyl-ethyl)-4 (trifluoromethylsulfanyl)-benzamide derivatives for use as nematocidal drugs; PCT/EP2014/064006.
[3] G. Gasser, R. B. Gasser, J. Hess, M. Patra, A. Jabbar. Bis-Organometallic 2-amino-3-hydroxy-2-methylpropanenitrile derivatives for use as anthelmintics; PCT/EP2014/070708.
[2] G. Gasser, R. B. Gasser, J. Hess, M. Patra and A. Jabbar. Organometallic compounds for use as anthelmintics; PCT/EP2014/070709.
[1] G. Gasser, R.B. Gasser, J. Hess, M. Patra and A. Jabbar. Organometallic N-2-cyano-1-hydroxyproban-2-yl for use as anthelmintics; PCT/EP2014/070707.
Reviews and Perspectives
[2] M. Patra, G. Gasser and N. Metzler-Nolte,* Small Organometallic Compounds as Antibacterial Agents, Dalton Trans., 2012, 41, 6350-6358.
[1] M. Patra and G. Gasser,* Organometallic Compounds, an Opportunity for Chemical Biology? ChemBioChem, 2012, 13, 1232-1252. (One of the most cited articles in ChemBioChem of the years 2012, 2013 and 2014.
Book Chapter
[1] T. Joshi,# M. Patra,# and G. Gasser,* (# = co-first authors). Other Applications of Metal Complexes in Chemical Biology, (In Inorganic Chemical Biology: Principles, Techniques and Applications, Ed. G. Gasser) John Wiley & Sons, Ltd, UK, 2014, 373-401. ISBN: 978-1-11851-002-5.
Publications
[22] M. Patra, T. Johnstone, K. Suntharalingam, and S. J. Lippard,* A Potent glucose-platinum conjugate exploits glucose-transporters and selectively accumulate in cancer cells. Angew. Chem. Int. Ed., 2015, in press. DOI: 10.1002/anie.201510551.
[21] M. Patra, M. Wenzel, P. Prochnow, V. Pierroz, G. Gasser, J. E. Bandow* and N. Metzler-Nolte*, Chem. Sci., 2015, 6, 214-224.
[20] M. Patra, A. Bauman, C. Mari, C. A. Fischer, O. Blacque, D. Haussinger, G. Gasser,* T. L. Mindt,* Chem. Commun., 2014, 50, 11523-11525.
[19] C. Mari, V. Pierroz, R. Rubbiani, M. Patra, J. Hess, B. Spingler, L. Oehninger, J. Schur, I. Ott, L. Salassa, S. Ferrari and G. Gasser*, Chem. Eur. J., 2014, 20, 14421-14436.
[18] I. Meister, K. Ingram-Sieber, N. Cowan, M. Todd, M. N. Robertson, C. Meli, M. Patra, G. Gasser and J. Keiser,* Antimicrob. Agents Chemother., 2014, 58, 5466-5472.
[17] M. Patra, K. Ingram, A. Leonidova, V. Pierroz, S. Ferrari, M. N. Robertson, M. H. Todd, J. Keiser,* G. Gasser,* J. Med. Chem., 2013, 56, 9191-9198.
[16] M. Patra,* J. Hess, S. Konatschnig, B. Spingler, G. Gasser,* Organometallics, 2013, 32, 6095-6105.
[15] A. Leonidova, T. Joshi, D. Nipkow, A. Frei, J.-E. Penner, S. Konatschnig, M. Patra, and G. Gasser, Organometallics 2013, 32, 2037-2040.
[14] T. Joshi, M. Patra, L. Spiccia and G. Gasser, Artificial DNA PNA & XNA, 2013, 4, 11-18
[13] M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, R.B. Gasser, J. Keiser and G. Gasser, Chem. Eur. J. 2013, 19, 2232-2235.
[12] M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, J. Keiser and G. Gasser, J. Med. Chem. 2012, 55, 8790-8798.
[11] M. Patra and G. Gasser, ChemBioChem, 2012, 13, 1232 – 1252.
[10] M. Patra, G. Gasser and N. Metzler-Nolte, Dalton Trans. 2012, 41, 6350-6358.
[9] M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow and N. Metzler-Nolte, Organometallics, 2012, 31, 5760–5771.
[8] M. Patra, K. Merz and N. Metzler-Nolte, Dalton Trans., 2011, 41, 112-117.
[7] M. Patra and N. Metzler-Nolte, Chem. Comm., 2011, 47, 11444-11446.
[6] M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow and N. Metzler-Nolte, Eur. J. Inorg. Chem. 2011, 3295-3302.
[5] M. Wenzel, M. Patra, D. Albrecht, D.Y.-K. Chen, K.C. Nicolaou, N. Metzler-Nolte, J.E. Bandow, Antimicrob. Agents. Chemother., 2011, 55, 2590-2596.
[4] M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow and N. Metzler-Nolte, Organometallics, 2010, 29, 4312-4319.
[3] M. Patra, G. Gasser, D. Bobukhov, K. Merz, A.V. Shtemenko and N. Metzler-Nolte, Dalton Trans, 2010, 39, 5617-5619.
[2] M. Patra, G. Gasser, K. Merz, I. Ott, J.E. Bandow and N. Metzler-Nolte, ChemMedChem, 2009, 4, 1930-1938.
[1] S. Maji, B. Sarkar, M. Patra, A.K. Das, S.M. Mobin, G.K. Lahiri, Inorg. Chem. 2008, 47, 3218-3227.