Maxime Klausen

Maxime Klausen
Assistant Professor
Chimie ParisTech
PSL University
CNRS
Institute of Chemistry for Life and Health Sciences
Laboratory for Inorganic Chemical Biology
+33 1 85 78 41 53
maxime.klausen@chimieparistech.psl.eu

Maxime Klausen is an Assistant Professor at Chimie ParisTech – PSL working in the Laboratory for Inorganic Chemical Biology. Born in Dax (France), he completed his PhD in Organic Chemistry at the University of Bordeaux (France) under the supervision of Dr. Mireille Blanchard-Desce, where his work focused on the design of molecular light-responsive drug-delivery systems, and two-photon responsive materials. Following his PhD, he joined the University of Edinburgh (UK) as Chemical Probe Design Research Associate and worked with Prof. Mark Bradley to develop probes for precision diagnostic and photodynamic therapy of infectious diseases. He then worked at the University of Oxford (UK) and the Kavli institute for Nanoscience Discovery, researching innovative stimulus-responsive biomaterials for tissue engineering and organoid development in the group of Prof. Dame Molly Stevens. His work currently spans across areas such as neurology, cancer therapy, antimicrobial resistance, and point-of-care diagnostics using light responsive molecules, polymers and nanoparticles. In his spare time, he enjoys video games, playing piano, history and literature, but also traveling and discovering new cultures.

Publications

  1. Lighting up Mycobacteria with membrane-targeting peptides. Z. S. Alghamdi, R. Sharma, M. Ucuncu, M. Klausen, M. Santra, U. Devi, S. Venkateswaran, A. Lilienkampf, M. Bradley*, Org. Biomol. Chem., 2024, 22, 8781-8786. DOI: 10.1039/D4OB01333F.
  2. Click Synthesis of Tweezer Dyads for H-Bond Assisted Cooperativity in Tandem Uncaging Systems, M. Klausen,§ V. Dubois,§ S. Picard, E. Cueto Diaz, J. Daniel, J.-B. Verlhac, M. Blanchard-Desce* Chem. – Eur. J., 2024, 30, e202402076. DOI: 10.1002/chem.202402076.
  3. A Dual Action Coumarin Camptothecin Polymer for Light Responsive Drug Release and Photodynamic Therapy. P. A. Shaw, M. Klausen,* M. Bradley, Polym. Chem., 2024, 15, 54–58. DOI: 10.1039/D3PY01137B.
  4. Riboflavin-Vancomycin Conjugate Enables Simultaneous Antibiotic Photo-Release and Photodynamic Killing against Resistant Gram-Positive Pathogens, B. Mills,*§ A. Kiang,§ S. M. P. C. Mohanan, M. Bradley, M. Klausen,* JACS Au, 2023, 3, 3014–3023. DOI: 10.1021/jacsau.3c00369.
  5. Fluorophore-tagged poly-Lysine RAFT agents: Controlled synthesis of trackable cell-penetrating polymers, P. A. Shaw, M. Klausen, A. Lilienkampf, M. Bradley,* ACS Macro Lett. 2023, 12, 1280–1285. DOI:10.1021/acsmacrolett.3c00460.
  6. Solid-Phase Synthesis of 1,2,4,5-Tetrazines, Z. Alghamdi, M. Klausen, A. Gambardella, A. Lilienkampf, M. Bradley,* Org. Lett., 2023, 25, 3104–3108. DOI:10.1021/acs.orglett.3c00955.
  7. Enhancing Two-Photon Uncaging Sensitivity in Symmetrical Dimeric Conjugated Coumarin Cages: Role of the Coupling Core, V. Dubois,§ M. Klausen,§ F. Castet, J.-B. Verlhac, M. Blanchard-Desce,* J. Photochem. Photobiol. A, 2023, 438, 114544. DOI:10.1016/j.jphotochem.2023.114544.
  8. Three-branched coumarin derivatives for two-photon uncaging of Glycine. How does branching influence the efficacy?, V. Dubois, M. Klausen, J. Daniel, F. Castet, S. Plaize, J.-B. Verlhac,* M. Blanchard-Desce*, Dyes Pigm. 2022, 110656. DOI: 10.1016/j.dyepig.2022.110656.
  9. Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent Gram positive probe, R. Sharma, H. Rajagopalan, M. Klausen, M. Vimalin Jeyalatha, M. Üçüncü, S. Venkateswaran, A. R. Anand* and M. Bradley,* Sens. Diagn. 2022, 1, 1014–1020. DOI:10.1039/D2SD00061J.
  10. Two-Photon Absorption: An Open Door to the NIR-II Biological Window?, P. A. Shaw, E. Forsyth, F. Haseeb, S. Yang, M. Bradley, M. Klausen,* Front. Chem. 2022, 10:921354. DOI: 10.3389/fchem.2022.921354.
  11. Two-Photon Uncaging of Bioactive Compounds: Starter Guide to an Efficient IR Light Switch, M. Klausen,* M. Blanchard-Desce,* J. Photochem. Phobiol. C: Photochemistry Reviews 2021, 48, 100423. DOI: 10.1016/j.jphotochemrev.2021.100423.
  12. Red-shifted environmental fluorophores and their use for the detection of Gram-negative bacteria, A. Megia-Fernandez,* M. Klausen, B. Mills, G. Brown, H. McEwan, N. Finlayson, K. Dhaliwal, M. Bradley, Chemosensors 2021, 9, 117. DOI: 10.3390/chemosensors9060117.
  13. Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy, M. Klausen,* M. Ucuncu,* M. Bradley, Molecules 2020, 25, 5239. DOI: 10.3390/molecules25225239.
  14. Fluorescent phosphorus dendrimers excited by two photons: synthesis, two-photon absorption properties and biological uses, A.-M. Caminade,* A. Zibarov, E. Cueto Diaz, A. Hameau, M. Klausen, K. Moineau-Chane Ching, J.-P. Majoral, J.-B. Verlhac, O. Mongin, M. Blanchard-Desce, Beilstein J. Org. Chem. 2019, 15, 2287–2303. DOI: 10.3762/bjoc.15.221.
  15. Tandem Systems for Two‐Photon Uncaging of Bioactive Molecules, M. Klausen, V. Dubois, J.-B. Verlhac*, M. Blanchard-Desce*, ChemPlusChem 2019, 84, 589–598. DOI: 10.1002/cplu.201900139.
  16. Dual-wavelength efficient two-photon photorelease of glycine by π-extended dipolar coumarins, M. Klausen,* V. Dubois, G. Clermont, C. Tonnelé, F. Castet, M. Blanchard-Desce*, Chem. Sci. 2019, 10, 4209–4219. DOI: 10.1039/C9SC00148D.
  17. Cooperative Veratryle and Nitroindoline Cages for Two-Photon Uncaging in the NIR, E. Cueto Diaz, S. Picard, M. Klausen, V. Hugues, P. Pagano, E. Genin, M. Blanchard-Desce*, Chem. – Eur. J. 2016, 22, 10848–10859. DOI: 10.1002/chem.201601109.
  18. Fluorescent periodic mesoporous organosilica nanoparticles dual-functionalized via click chemistry for two-photon photodynamic therapy in cells, J. G. Croissant, S. Picard, D. Aggad, M. Klausen, C. Mauriello Jimenez, M. Maynadier, O. Mongin, G. Clermont, E. Genin, X. Cattoën, M. Wong Chi Man, L. Raehm, M. Garcia, M. Gary-Bobo,* M. Blanchard-Desce*, J.-O. Durand*, J. Mater. Chem. B 2016, 4, 5567–5574. DOI: 10.1039/C6TB00638H.

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